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From 1981 to 1993, Dr. Silberklang worked for the Merck Research Laboratories in Rahway, New Jersey, initially in gene cloning and expression, and recombinant gene-derived protein production, and later in cell culture process scale-up and research and development. From 1988 to 1993 Dr. Silberklang was Associate Director of Cell and Molecular Biology, in which capacity he directed development of scaleable cell culture processes and produced cells, viruses (for vaccines) and recombinant proteins for preclinical and clinical uses. From 1993 to 1995, Dr. Silberklang was Senior Director of Process Research and Development at Enzon, Inc., where he developed and implemented a bioreactor process for baculovirus-directed production of recombinant Glucocerebrosidase for a clinical trial.
Since 1995, Dr. Silberklang has worked for Ortec International, Inc. and is responsible for basic and applied research, including bioprocess development and pilot production of a human cultured skin product for clinical trials. He has worked and published extensively in the areas of cell culture medium development, cell culture process research and development, and bioreactor process design.
Dr. Silberklang obtained his Ph.D. in biochemistry from M.I.T. in 1977, and did postdoctoral work in Drosophila molecular genetics and cell biology at the University of California at San Francisco. | 