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Dr. Bolen joined Millennium in 1999 as Vice President of Oncology and was promoted to Senior Vice President of Discovery Research in 2002. In this role, he headed all biological research in the areas of oncology, inflammation, metabolic disease and cardiovascular disease as well as all genomics, informatics and platform technologies.
In 2003 Dr. Bolen was appointed Senior Vice President of Research and Drug Discovery, a role in which he heads all biological research and related functions as well as all drug discovery functions. Dr. Bolen was appointed Chief Scientific Officer in 2006.
Prior to joining Millennium, Dr. Bolen was Vice President of Oncologic Diseases at Hoechst Marion Roussel. Previously, Dr. Bolen served as the Director of the Cellular Signaling Department at the DNAX Research Institute of Molecular and Cellular Biology (a functional genomics and research division of Schering-Plough) in Palo Alto, California. At DNAX, Dr. Bolen was involved in immunology and oncology research and development efforts. Earlier in his career, Dr. Bolen was Executive Director of Oncology Drug Discovery at the Bristol-Myers Squibb Pharmaceutical Research Institute, Professor and Member of the Graduate Faculty at Princeton University in the Department of Molecular Biology. During this period, Dr. Bolen also served as a Graduate Advisor in the Physiology and Neurobiology Program at the Robert Wood Johnson Medical School.
Dr. Bolen graduated from the University of Nebraska with a B.S. degree in Microbiology and Chemistry and a Ph.D. in Immunology. He pursued post-doctoral training in Molecular Virology at the Kansas State University Cancer Center, where his research was directed towards analysis of the DNA Tumor Virus, Polyoma. Dr. Bolen then joined the National Institutes of Health as a member of the Laboratory of Molecular Microbiology, where his research focus turned to the protein tyrosine kinase class of oncogenes. A founding member of the Laboratory of Tumor Virus Biology, Dr. Bolen also joined the National Cancer Institute and was appointed Chief of the Biochemical Oncology Section.
Dr. Bolen received the National Institutes of Health Award for Meritorious Research in 1990 for his key contributions to the discovery of the normal physiologic functions of the src group of protein tyrosine kinase oncogenes as key regulators of the immune system. Dr. Bolen has published more than 200 peer-reviewed scientific articles and book chapters and has served on several journal editorial boards, including the Journal of Virology, Molecular and Cellular Biology, and Current Topics in Virology. Dr. Bolen has served on numerous study sections, panels and committees for the National Institutes of Health, the National Aeronautics and Space Administration, and the Howard Hughes Medical Institute. Dr. Bolen also served as a member of the Scientific Advisory Board for the Center for Advanced Biotechnology and Medicine at the University of Medicine and Dentistry of Rutgers University and is currently a member of the Scientific Advisory Board for the Hollings Cancer Center.
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