Ms. Spinella has served as Vice President Regulatory Affairs and Quality Assurance of Cardium Therapeutics since November 2005 and as Vice President Regulatory Affairs and Quality Affairs for InnerCool Therapies since it was acquired by Cardium in March 2006 and of Tissue Repair Company since August 2006, each a wholly-owned subsidiary of Cardium. Before joining Cardium, Ms. Spinella was Director of Regulatory Affairs at Biogen Idec Inc. and was responsible for the regulatory strategy and recent supplemental Biologics License Application (sBLA) for Rituxan® in rheumatoid arthritis. Before joining Biogen Idec in 2003, she was Director of Regulatory Affairs at Idun Pharmaceuticals Inc. and held various regulatory positions at Elan Pharmaceuticals Inc., Chugai Biopharmaceuticals Inc., Dura Pharmaceuticals Inc. and Gensia, Inc. Ms. Spinella earned her B.S. in Medical Technology from the University of Nebraska College of Medicine, Omaha, Nebraska.