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Mr. Smith currently serves as our Executive Vice President and Chief Financial Officer a position he has held since February 2006. From November 2003 to February 2006 he was our Senior Vice President and Chief Financial Officer and from October 2001 to November 2003 he served as our Vice President and Chief Financial Officer. Prior to joining Vertex Mr. Smith served as a partner in the Life Science and Technology Practice Group of Ernst & Young LLP an accounting firm from 1999 to 2001. Mr. Smith initially joined Ernst & Young’s U.K. firm in 1987 and then joined its Boston office in 1995. Mr. Smith currently is a member of the Board of Directors of Acorda Therapeutics Inc Epix Pharmaceuticals Inc. and TolerRx Inc. Mr. Smith holds a B.A. in accounting and finance from Manchester Metropolitan University U.K. is a member of the American Institute of Certified Public Accountants and is a Chartered Accountant of England and Wales. | 