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Bachchu Lal, Ph.D., is a research associate in the Department of Neurology at Kennedy Krieger Institute.
Biographical Sketch:
Dr. Lal received a bachelor of science in zoology, botany and chemistry from Lucknow University in Lucknow, UP, India in 1977, followed by a master of science in zoology and a Ph.D in zoology from Kanpur University in Kanpur, UP, India. Dr. Lal completed a postdoctoral fellowship from Johns Hopkins University School of Medicine with the Department of Neurology at Kennedy Krieger Institute and joined the faculty of Kennedy Krieger Institute in 2001 as a research scientist. Dr. Lal is currently a Research Associate in the Department of Neurology at Kennedy Krieger.
Research Summary:
Dr. Lal’s recent clinical research interests include the growth, detection and malignancy of brain tumors. His main focus is to treat brain tumors expressing scatter factor/ hepatocyte growth factor. He is using monoclonal antibody targeting scatter factor/ hepatocyte growth factor besides other therapeutics, to induce the regression of intracranial glioma xenografts. Additionally, Dr. Lal has been awarded several major grants with which to study the biochemistry of brain tumor microvessel development, the mechanisms of chemo/radioresistance in human gliomas, and the development of novel magnetic resonance imaging and spectroscopy metholodgies for tumor detection.
Recent Publications/Presentations:
K.Jin Kim, Lihong Wang, Yi-Chi Su, G. yancey Gillespie, Amandeep Salhotra, Bachchu Lal and John Laterra. Systemic anti-hepatocyte growth factor monclonal antibody therapy induces the regression of intracranial glioma xenografts. Clinical Cancer Research; 12(4), 2006.
Li Y, Lal B, Kwon S, Fan X, Saldanha U, Reznik TE, Kuchner EB, Eberhart C, Laterra J, Abounader R. The scatter factor/hepatocyte growth factor: c-met pathway in human embryonal central nervous system tumor malignancy. Cancer Res; 65, 9355-9362, 2005.
Bachchu Lal, Shuli Xia, Roger Abounader and John Laterra. Targeting the c-Met pathway potentiates glioblastoma response to gama radiation. Clinical Cancer Research; 11, 4479-4486, 2005. | 