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Ann Moser is a Research Associate in Neurology at Kennedy Krieger Institute and Johns Hopkins University.
Biographical Sketch:
Ms. Moser received a bachelor’s degree in Biochemistry in 1961 from Radcliffe College. During the time she was an undergraduate, she was a Technician in Dr. Konrad Bloch’s laboratory at Harvard University. After working as a Technician in laboratories in different hospitals, Ms. Moser joined the John F. Kennedy Institute (later Kennedy Krieger Institute) in 1976 as a Senior Technician. In 1982, she became an Assistant in Neurology. Since 1991, Ms. Moser has been working as a Research Associate in Neurology. She is the Lab Manager for the Peroxisomal Diseases Laboratory.
Research Summary:
The peroxisomal Diseases Lab receives approximately 100 blood samples per week for the analysis of total lipid fatty acids, including the very long chain fatty acids, essential fatty acids, and branched chain fatty acids. Individuals with increased plasma, very long chain fatty acids and or branched chain fatty acids have disorders of peroxisomal metabolism. The peroxisomal disorders include patients with X-linked adrenoleukodystrophy, Zellweger syndrome, and Refsum’s disease. Under the guidance of Drs. Hugo Moser and Gerald Raymond we are measuring the plasma and red blood cell fatty acids to follow the therapy of peroxisomal disorders with oils such as Lorenzo’s oil and fish or algae oils (high w3 fatty acid oils). NIH and the FDA fund these studies. Our lab is collaborating with other researchers at Johns Hopkins, The Kennedy Krieger Institute and at other Medical Universities. We measure plasma and red blood cell fatty acids in patients with other diseases such as retinitis pigmentosa, heart disease, cystic fibrosis, type 2 diabetes, chronic seizure disorders, Downs syndrome, ADHD, Alzheimer disease, kidney transplant recipients and autism. In addition to our human fatty acid analyses, we provide fatty acid analyses for various transgenic mouse models including the Zellweger mouse, the X-linked adrenoleukodystrophy mouse, and the obese mouse.
RESEARCH PARTICIPANTS NEEDED:Adrenomyeloneuropathy (AMN) Research Study
Recent Publications/Presentations:
Moseley K, Koch R, Moser AB, 2002. Lipid status and long-chain polyunsaturated fatty acid concentrations in adults and adolescents with phenylketonuria on phenylalanine-restricted diet. J. Inherit. Metab. Dis. 25, 56-64.
Tagawa Y, Laroy W, Nimrichter L, Fromholt SE, Moser AB, Moser HW and Schnaar RL, 2002. Anti-ganglioside antibodies bind with enhanced affinity to gangliosides containing very long chain fatty acids. Neurochem Res 27:847-855.
Faust PL, Su H-M, Moser A, , Moser HW, 2001. The Peroxisome Deficient PEX2 Zellweger Mouse. J of Molecular Neuroscience. 16:289-297.
Su H-M, Moser AB, Moser HW, Watkins PA, 2001. Peroxisomal Straight-chain Acyl-CoA Oxidase and D-bifunctional Protein Are Essential for the Retroconversion Step in Docosahexaenoic Acid Synthesis. J Bio Chem 276(41):38115-38120.
Wei H, Kemp S, McGuinness MC, Moser AB, Smith KD, 2000. Pharmacological induction of peroxisomes in peroxisome biogenesis disorders. Ann Neurol. (3):286-96.
Braverman N, Steel G, Lin P, Moser A, Moser H, Valle D, 2000. PEX7 Gene Structure, Alternative Transcripts, and Evidence for a Founder Haplotype for the Frequent RCDP Allele, L292ter. Genomics 63, 181-192. |
